Glaucoma in the Hallermann-Streiff syndrome.

The Hallermann-Streiff syndrome is a complex association of developmental anomalies principally involving structures of ectodermal origin. The constant expressions of the syndrome are dyscephaly with mandibulo-facial malformation, bilateral congenital cataracts, and dental anomalies, while hypotrichosis, cutaneous atrophy, microphthalmos, and proportionate dwarfism are frequently present (Table I) (Ponte, I962). Numerous inconstant ocular features have been described, including anti-mongoloid palpebral fissures, blue sclerae, keratoglobus, malformation of the drainage angles, peripheral anterior synechiae, iris atrophy, persistent pupillary membrane, posterior synechiae, membranous cataract, amorphous retrolenticular membrane, vitreous opacities, pale optic discs, colobomata at the optic nerve entrance, retinal folds, various atrophic chorioretinal changes and glaucoma (Table II) (Ludwig and Korting, I950; Fransois, I958; Falls and Schull, I 960; Wolter and Jones, I 965; Ide and Webb, I 969).